Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

长期以来，我们习惯于将基因组比作一本厚重的“生命天书”。过去的几十年，研究人员的主要工作是“阅读”，通过测序技术解读其中的碱基排列；后来，CRISPR ...

Researchers are investigating the role of non-coding DNA, or junk DNA, in regulating astrocytes, brain cells involved in ...

Switches' in our DNA that affect gene activity in cells could be crucial to understanding and possibly treating Alzheimer's ...

Researchers at the Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence (AI) to design thousands of new DNA switches that can ...

A new CRISPR breakthrough shows scientists can turn genes back on without cutting DNA, by removing chemical tags that act ...

Professor Asaf Hellman and his research team at the Hebrew University-Hadassah Medical School have unveiled new findings in the realm of methylation-directed regulatory networks. Their study sheds ...

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published ...

Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence. 1 The name epigenetics comes from the Greek prefix “epi”, which means on top ...